Aikace-aikacen asibiti da Bincike na PRP a cikin Ciwon Knee na Jama'a

Aikace-aikacen asibiti da bincike na PRP a cikin cututtuka na kowa na haɗin gwiwa gwiwa

Platelet-rich Plasma (PRP) plasma ne wanda ya ƙunshi mafi yawan platelets da fararen jini wanda aka samo ta hanyar centrifugation na jini na gefe.An adana babban adadin abubuwan girma da cytokines a cikin α granules na platelet.Lokacin da aka kunna platelets, granules ɗin su na α suna sakin adadi mai yawa na abubuwan haɓaka.Nazarin ya nuna cewa waɗannan abubuwan haɓakar ƙwayoyin cuta na iya haɓaka bambance-bambancen tantanin halitta, haɓakawa, matrix extracellular da collagen synthesis, don haka inganta haɓakawa da gyaran gyare-gyaren guringuntsi da ligament.saurankyallen takarda.A lokaci guda kuma, yana iya inganta haɓakar ƙwayar cuta ta wurin raunin da kuma rage alamun asibiti na marasa lafiya.Baya ga waɗannan abubuwan haɓakar ƙwayoyin sel, PRP kuma ya ƙunshi babban adadin fararen ƙwayoyin jini.Wadannan fararen sel da platelets na iya sakin nau'ikan peptides na antimicrobial don ɗaure ga ƙwayoyin cuta, hanawa da kashe ƙwayoyin cuta, kuma suna taka rawar kashe ƙwayoyin cuta.

An yi amfani da PRP sosai a fagen ilimin orthopedics saboda tsarin masana'anta mai sauƙi, amfani mai dacewa da ƙananan farashi, musamman a cikin maganin cututtuka na gwiwa a cikin 'yan shekarun nan.Wannan labarin zai tattauna aikace-aikace na asibiti da bincike na Plasma-arziki a cikin osteoarthritis na gwiwa (KOA), raunin meniscus, raunin ligament na cruciate, synovitis gwiwa da sauran cututtuka na gwiwa.

Fasahar aikace-aikacen PRP

PRP da ba a kunna ba da kuma sakin PRP da aka kunna suna da ruwa kuma ana iya allura, kuma PRP ɗin da ba a kunna ba za a iya sarrafa shi ta hanyar artificially ƙara calcium chloride ko thrombin don sarrafa lokacin agglutination ta yadda za a iya samar da gel bayan isa wurin da aka yi niyya, don haka cimma manufar ci gaba da sakin abubuwan girma.

PRP jiyya na KOA

KOA cuta ce mai lalacewa ta gwiwa wacce ke nuna ci gaba da lalacewa na guringuntsi na articular.Yawancin marasa lafiya sun kasance masu matsakaici da tsofaffi.Bayanan asibiti na KOA sune ciwon gwiwa, kumburi, da iyakancewar aiki.Rashin daidaituwa tsakanin kira da bazuwar matrix articular guringuntsi shine tushen abin da ya faru na KOA.Saboda haka, inganta gyaran guringuntsi da daidaita ma'auni na matrix na guringuntsi shine mabuɗin magani.

A halin yanzu, yawancin marasa lafiya na KOA sun dace da magani mai ra'ayin mazan jiya.Allurar haɗin gwiwa na gwiwa na hyaluronic acid, glucocorticoids da sauran magunguna da na baka waɗanda ba steroidal anti-kumburi kwayoyi ana amfani da mazan jiya magani.Tare da zurfafa bincike a kan PRP ta malaman gida da na waje, maganin KOA tare da PRP ya zama mafi girma a cikin 'yan shekarun nan.

Hanyar aiki:

1. Inganta yaduwar chondrocytes:

Ta hanyar auna tasirin PRP akan iyawar chondrocytes zomo, Wu J et al.ya gano cewa PRP ya haɓaka haɓakar ƙwayoyin chondrocytes, kuma ya yi hasashen cewa PRP na iya kare IL-1β-activated chondrocytes ta hanyar hana watsa siginar Wnt / β-catenin.

2. Hana maganin kumburi na chondrocyte da lalata:

Lokacin da aka kunna, PRP ta saki babban adadin abubuwan da ke hana kumburi, irin su IL-1RA, TNF-Rⅰ, ⅱ, da dai sauransu Il-1ra na iya hana IL-1 kunnawa ta hanyar toshe mai karɓar IL-1, da TNF-Rⅰ da ⅱ na iya toshe hanyar sigina mai alaƙa da TNF-α.

Nazarin inganci:

Babban bayyanar cututtuka shine taimako na ciwo da inganta aikin gwiwa.

Lin KY et al.idan aka kwatanta da allurar intra-articular na LP-PRP tare da hyaluronic acid da saline na al'ada, kuma sun gano cewa tasirin warkewa na ƙungiyoyi biyu na farko ya fi na rukunin saline na al'ada a cikin ɗan gajeren lokaci, wanda ya tabbatar da tasirin asibiti na LP-PRP. da hyaluronic acid, da kuma lura na dogon lokaci (bayan 1 shekara) ya nuna cewa tasirin LP-PRP ya fi kyau.Wasu nazarin sun haɗu da PRP tare da hyaluronic acid, kuma sun gano cewa haɗin PRP da hyaluronic acid ba zai iya kawar da ciwo kawai da inganta aikin ba, amma kuma ya tabbatar da sake farfadowa na guringuntsi ta hanyar X-ray.

Koyaya, Filardo G et al.sun yi imanin cewa ƙungiyar PRP da ƙungiyar hyaluronate sodium suna da tasiri wajen inganta aikin gwiwa da alamun cututtuka ta hanyar binciken da bazuwar bazuwar, amma babu wani bambanci mai mahimmanci.An gano cewa hanyar gwamnatin PRP tana da wani tasiri akan tasirin warkewa na KOA.Du W et al.bi da KOA tare da alluran intravarticular na PRP da alluran extraarticular, kuma an lura da maki VAS da Lysholm kafin magani da watanni 1 da 6 bayan magani.Sun gano cewa duka hanyoyin allura na iya inganta maki VAS da Lysholm a cikin ɗan gajeren lokaci, amma tasirin ƙungiyar allurar intra-articular ya fi ƙungiyar allura ta waje bayan watanni 6.Taniguchi Y et al.An raba binciken akan maganin KOA mai matsakaici zuwa mai tsanani a cikin allurar intraluminal hade tare da allurar intraluminal na ƙungiyar PRP, allurar intraluminal na ƙungiyar PRP da intraluminal na ƙungiyar HA.Binciken ya nuna cewa haɗuwa da allurar intraluminal na PRP da alluran intraluminal na PRP ya fi alluran intraluminal na PRP ko HA na akalla watanni 18 don inganta ƙimar VAS da WOMAC.

(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)