Primary atrophic rhinitis (1Ry AR) cuta ce ta hanci na yau da kullun wacce ke da asarar aikin sharewar mucociliary, kasancewar ɓoye mai ɗanɗano da busassun ɓawon burodi, wanda ke haifar da wari na yau da kullun, yawanci biyu.An yi ƙoƙari mai yawa na hanyoyin jiyya, amma har yanzu ba a sami yarjejeniya kan nasarar maganin warkewa na dogon lokaci ba.Manufar wannan binciken shine don kimanta ƙimar plasma mai arzikin platelet a matsayin abin motsa jiki don inganta warkar da rhinitis na farko na atrophic.
Marubucin ya haɗa da jimlar 78 lokuta na asibiti da aka gano tare da na farko atrophic rhinitis.Rukunin A (masu kararraki) da marasa lafiya da ke da ƙarancin platelet an yi amfani da su ta hanci endoscopy, Sakamakon Sakamakon Sino Nasal-25 tambayoyin tambayoyi, gwajin lokacin saccharin don kimanta ƙimar izinin ciliary na mucosal, da plasma a cikin samfurin biopsy rukunin B (control) wata 1 da watanni 6 kafin aikace-aikacen. rage yawan adadin platelet.
Mafi yawan bayyanar cututtuka da duk marasa lafiya suka fuskanta a cikin rukuni na A kafin allura na plasma mai arziki a cikin platelet sun hada da scab scab, wanda ya nuna haɓakar endoscopic da raguwa, tare da lokuta 36 (92.30%);masu adawa, 31 (79.48%);Ciwon hanci, 30 (76.92%);Rashin wari, 17 (43.58%);Da kuma epistaxis, 7 (17.94%) zuwa scab na hanci, 9 (23.07%);Kafa, 13 (33.33%);Ciwon hanci, 14 (35.89%);Rashin wari, 13 (33.33%);Kuma epistaxis, 3 (7.69%), bayan watanni 6, wannan yana nunawa a cikin raguwa a cikin sakamakon gwajin gwajin hanci na Sino-25, wanda ya kai 40 kafin plasma mai arzikin platelet kuma ya ragu zuwa 9 bayan watanni 6.Hakazalika, an rage lokacin cirewar mucociliary sosai bayan allurar da ke da wadataccen jini na platelet;Matsakaicin lokacin jigilar saccharin na farko shine daƙiƙa 1980, kuma ya ragu zuwa daƙiƙa 920 watanni 6 bayan allurar plasma mai arzikin platelet.
Yin amfani da jini mai wadataccen jini na platelet a matsayin wakili na halitta na iya zama wata sabuwar hanya ta mamayewa wacce zata iya gyara rashin abinci mai gina jiki yadda yakamata ta hanyar ƙarin bincike.
Akwai manyan hanyoyi guda hudu don magance rhinitis na atrophic: kunkuntar kogon hanci da abubuwa daban-daban da abubuwan da aka sanyawa, inganta farfadowa na mucosal na yau da kullun ta amfani da aikin tiyata na Yang na gargajiya ko gyare-gyare, sa mai ga hancin mucosa, ko inganta hanyoyin jini na hanci.Kogo.An gwada wasu hanyoyin magani da yawa, ciki har da ban ruwa na hanci da flushing, glucose glycerol nasal drops, water paraffin, estradiol a cikin man gyada, maganin anti ozaena, maganin rigakafi, baƙin ƙarfe, zinc, furotin, bitamin kari, vasodilators, prostheses, alluran rigakafi, cirewar placental. ko acetylcholine, tare da ko ba tare da pilocarpine ba.Koyaya, tasirin waɗannan hanyoyin ya bambanta.A aikin likitanci, kurkure kogon hanci da feshin hanci shine hanyar da aka fi amfani da ita wajen magance alamun rashin lafiyar rhinitis, domin yana iya jikan gabobin hanci da kuma hana tabo.
Daga cikin hanyoyin da aka ambata a sama, an tabbatar da ingantaccen aikin tiyata na Yang hanya ce mai inganci kuma mai dawwama don magance cututtukan rhinitis na atrophic.Duk da haka, sakamakon buɗaɗɗen baki na iya haifar da rashin jin daɗi ga marasa lafiya.An nuna masu lubricants da kari suna da iyakancewa da tasiri na gajeren lokaci.Sabili da haka, an yi nazarin wasu hanyoyin da za a inganta farfadowa na mucosal na hanci ko angiogenesis.
PRPyana kunshe da ma'auni na plasma wanda ya wuce adadin platelet a cikin jini duka.PRP yana haɓaka abubuwan da ke shafar haɓakar nama, bambance-bambance, da warkar da tabo, irin su nau'in haɓakar haɓakar platelet, canjin haɓakar girma, ma'aunin haɓakar fibroblast, haɓakar haɓakar endothelial, da yanayin haɓaka kamar insulin.Sabili da haka, an tabbatar da PRP don samun sakamako mai kyau mai karɓa a cikin nazarin asibiti daban-daban, yadda ya kamata inganta warkar da raunuka da farfadowa na nama, ciki har da a fagen otolaryngology.Bugu da ƙari, an bayar da rahoton cewa PRP yana da tasiri wajen inganta farfadowa na tympanic membrane, muryar murya da jijiyar fuska, da kuma warkarwa bayan myringoplasty ko endoscopic sinus tiyata.Bugu da ƙari, an gudanar da binciken matukin jirgi a 'yan shekarun da suka gabata don magance rhinitis na atrophic tare da allura na cakuda PRP na lipid.Bugu da ƙari, PRP yana amfani da jini na autologous kuma ba shi da wani rashin lafiyan ko rashin lafiyar rigakafi.Ana iya shirya shi cikin sauƙi a cikin 'yan mintuna kaɗan ta hanyar matakai biyu na centrifugation.
A cikin wannan binciken, mun bincika allurar PRP a cikin mucosa na hanci na atrophic, wanda ya inganta ƙwayar mucosal cilia da alamun bayyanar cututtuka a lokacin watanni na watanni 6, musamman a cikin matasa marasa lafiya, tare da ƙarin sakamako mai mahimmanci idan aka kwatanta da ƙungiyar tsofaffi.A yawancin lokuta na rhinitis na atrophic, ciki har da tsofaffin rhinitis, ƙwayar ƙwayar cuta ta rage.Saboda haka, mucinous thickening take kaiwa zuwa jinkirta yarda na hanci mucosal cilia.Cika ruwa ta hanyar fesa saline zai shafi kaddarorin gabobin viscous, kuma za a dawo da sharewar cilia ta hanci zuwa wani matsayi.Koyaya, rawar da aka diluted na hancin hanci don magance alamun hanci na iya iyakancewa.Sabili da haka, ko da yake hydration na hanci mai ra'ayin mazan jiya na iya haɓaka ƙwayar mucociliary, wannan tsarin kulawa bai inganta alamun hanci ba sosai.Bugu da ƙari, feshin hanci da ban ruwa yana buƙatar salin ilimin lissafi da kayan aiki na musamman, kuma ya kamata a aiwatar da shi akai-akai don sarrafa alamun.Sabanin haka, allurar PRP tana buƙatar allura ɗaya kawai don cimma sakamako mai kyau.Bayan allura, ƙarar turbinate nan da nan yana ƙaruwa.Koyaya, a ziyarar mara lafiya ta gaba (makonni 2 bayan haka), babu bambanci a cikin girma da siffar turbinate na ƙasa.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Ruwan hanci da ban ruwa yana buƙatar salin ilimin lissafi da kayan aiki na musamman, kuma yakamata a aiwatar da shi akai-akai don sarrafa alamun.Sabanin haka, allurar PRP tana buƙatar allura ɗaya kawai don cimma sakamako mai kyau.Bayan allura, ƙarar turbinate nan da nan yana ƙaruwa.Koyaya, a ziyarar mara lafiya ta gaba (makonni 2 bayan haka), babu bambanci a cikin girma da siffar turbinate na ƙasa.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Ruwan hanci da ban ruwa yana buƙatar salin ilimin lissafi da kayan aiki na musamman, kuma yakamata a aiwatar da shi akai-akai don sarrafa alamun.Sabanin haka, allurar PRP tana buƙatar allura ɗaya kawai don cimma sakamako mai kyau.Bayan allura, ƙarar turbinate nan da nan yana ƙaruwa.Koyaya, a ziyarar mara lafiya ta gaba (makonni 2 bayan haka), babu bambanci a cikin girma da siffar turbinate na ƙasa.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Allurar PRP tana buƙatar allura ɗaya kawai don samun sakamako mai kyau.Bayan allura, ƙarar turbinate nan da nan yana ƙaruwa.Koyaya, a ziyarar mara lafiya ta gaba (makonni 2 bayan haka), babu bambanci a cikin girma da siffar turbinate na ƙasa.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Allurar PRP tana buƙatar allura ɗaya kawai don samun sakamako mai kyau.Bayan allura, ƙarar turbinate nan da nan yana ƙaruwa.Koyaya, a ziyarar mara lafiya ta gaba (makonni 2 bayan haka), babu bambanci a cikin girma da siffar turbinate na ƙasa.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Babu bambanci a cikin girma da siffar ƙananan turbinate.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.Babu bambanci a cikin girma da siffar ƙananan turbinate.Don haka, ana ɗaukar ƙarar ƙarar ɗan lokaci ta hanyar allura.Bugu da ƙari, kamar yadda aka nuna a cikin bincike na yanki na SNOT-22, babu wani ci gaba mai mahimmanci a cikin yanki na tunanin tunanin marasa lafiya na PRP.Sakamakon ba a haɗa shi da haɓakawa a cikin yanki na tunani ba, yana nuna cewa tasirin placebo ba shi da mahimmanci a wani bangare.
Ci gaba da ciwo da rashin jin daɗi da ke da alaƙa da alamun atrophic rhinitis ba su da tsanani a magani.Don haka, ba a yi la'akari da asarar zamantakewa da tattalin arziki.Duk da haka, daga hangen nesa na ainihin marasa lafiya, cuta ce mai mahimmanci na zamantakewa.Bugu da ƙari, tare da tsufa na yawan jama'a, yawan marasa lafiya tare da rhinitis na tsofaffi suna ƙara girma girma.Sabili da haka, yana da matukar muhimmanci a ba da magani mai dacewa don rhinitis na atrophic, ciki har da tsofaffin rhinitis.
Manufar wannan binciken ita ce ba da shawarar sabuwar hanyar farfadowa don magance rhinitis na atrophic ta hanyar allurar PRP ta autologous, da kuma kwatanta ingantaccen bayyanar cututtuka tsakanin ƙungiyar kulawa ta PRP da ƙungiyar kulawa ta ra'ayin mazan jiya ta amfani da ƙungiyar kulawa.Saboda atrophic rhinitis kasancewa ma'anar asibiti, ana buƙatar ƙarin bincike don fahimtar yanayin aikinsa.Koyaya, don hana asarar zamantakewa da tattalin arziƙi da raguwar ingancin rayuwa mai haƙuri, ya zama dole don samar da sakamakon bincike tare da tasirin warkewa.
Koyaya, wannan binciken yana da iyakancewa da yawa.An tsara wannan binciken na gaba kuma ba za a iya sarrafa shi ba kamar yadda wasu mahalarta suka ƙi shirin allurar hanci.Dangane da ɗabi'a, ayyukan cin zarafi don dalilai na ilimi a cikin ƙungiyar kulawa yakamata a iyakance su don kare haƙƙoƙin da bukatun marasa lafiya.Sabili da haka, sanya marasa lafiya bisa ga abubuwan da suke so ya sa sakamakon binciken ya yi rauni fiye da waɗanda aka ba da su ta hanyar binciken da aka bazu.Bugu da ƙari, rhinitis na biyu na atrophic yana haifar da lalacewa da kuma kawar da tsarin hanci na asali.Yin biopsy na iya kara tsananta atrophy.Sabili da haka, daga hangen nesa na ɗabi'a, ba shi yiwuwa a yi daidaitaccen ƙwayar ƙwayar hanci a cikin marasa lafiya tare da rhinitis atrophic.Sakamakon bayan watanni 6 na biyo baya bazai wakiltar sakamako na dogon lokaci ba.Bugu da ƙari, adadin marasa lafiya a cikin rukunin ƙananan ƙananan ne.Sabili da haka, bincike na gaba ya kamata ya haɗa da ƙarin marasa lafiya ta yin amfani da ƙirar da aka tsara a kan lokaci mai tsawo.
(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)
Lokacin aikawa: Mayu-23-2023