Platelets, a matsayin gutsutsayen sel daga marrow megakaryocytes, ana siffanta su da rashi na tsakiya.Kowane platelet ya ƙunshi nau'ikan barbashi guda uku, wato α Granules, jiki mai yawa da lysosomes masu adadi daban-daban.Ciki har da α The granules suna da wadata a fiye da 300 sunadaran sunadaran daban-daban, irin su jijiyar endothelial activating factor, leukocyte chemotactic factor, activating factor, gyara nama mai alaka da girma factor da kuma antibacterial peptide, wanda ke da hannu a da yawa physiological da pathological tafiyar matakai, kamar rauni waraka. , angiogenesis da rigakafi na rigakafi.
Jiki mai yawa ya ƙunshi babban adadin adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2+ da 5-hydroxytryptamine.Lysosomes sun ƙunshi nau'ikan proteases na sukari iri-iri, kamar glycosidases, proteases, sunadaran cationic da sunadaran da ke da aikin ƙwayoyin cuta.Ana fitar da waɗannan GF cikin jini bayan kunna platelet.
GF yana haifar da amsawar cascade ta hanyar ɗaure tare da nau'ikan masu karɓa na membrane daban-daban, kuma yana kunna takamaiman ayyuka a cikin aiwatar da sabunta nama.A halin yanzu, mafi yawan binciken GF shine nau'in haɓakar haɓakar platelet (PDGF) da canza yanayin girma (TGF- β （TGF- β）), Fatar haɓakar haɓakar ƙwayar ƙwayar cuta (VEGF), Factor girma na epidermal (EGF), Fatar haɓakar fibroblast (FGF), connective tissue growth factor (CTGF) da kuma insulin-like growth factor-1 (IGF-1) Wadannan GFs suna taimakawa wajen gyara tsoka, tendon, ligament da sauran kyallen takarda ta hanyar inganta yaduwar kwayar halitta da bambance-bambance, angiogenesis da sauran matakai, sa'an nan kuma yin wasa mai dacewa. rawar.
Aikace-aikacen PRP a cikin Vitiligo
Vitiligo, a matsayin na kowa autoimmune cuta, kazalika da ƙarar rashin lafiyan fata cuta, yana da mummunan tasiri a kan ilimin halin dan Adam na marasa lafiya da tsanani shafi ingancin rayuwar marasa lafiya.Don taƙaitawa, abin da ya faru na vitiligo shine sakamakon hulɗar kwayoyin halitta da abubuwan muhalli, wanda ke haifar da melanocytes na fata don kai hari da lalacewa ta hanyar tsarin jiki.A halin yanzu, ko da yake akwai jiyya da yawa don vitiligo, tasirin su sau da yawa yana da rauni, kuma yawancin jiyya ba su da shaidar shaidar magani.A cikin 'yan shekarun nan, tare da ci gaba da bincike na pathogenesis na vitiligo, an yi amfani da wasu sababbin hanyoyin magani akai-akai.A matsayin hanya mai mahimmanci don magance vitiligo, an ci gaba da amfani da PRP.
A halin yanzu, 308 nm excimer Laser da 311 nm kunkuntar band ultraviolet (NB-UVB) da sauran fasahar phototherapy ana ƙara gane su don ingancin su a cikin marasa lafiya tare da vitiligo.A halin yanzu, yin amfani da allurar microneedle na subcutaneous PRP tare da phototherapy a cikin marasa lafiya tare da barga vitiligo ya sami babban ci gaba.Abdelghani et al.An gano a cikin binciken su cewa allurar microneedle mai sarrafa kansa ta PRP tare da NB-UVB phototherapy na iya rage yawan lokacin jiyya na marasa lafiya na vitiligo.
Khattab et al.bi da marasa lafiya tare da barga ba segmental vitiligo tare da 308 nm excimer Laser da PRP, kuma sun sami sakamako mai kyau.An gano cewa haɗuwa da su biyun na iya inganta ƙimar recolor leukoplakia yadda ya kamata, rage lokacin jiyya, da kuma guje wa mummunan sakamako na dogon lokaci na amfani da 308nm excimer Laser irradiation.Wadannan nazarin sun nuna cewa PRP tare da phototherapy hanya ce mai mahimmanci don maganin vitiligo.
Duk da haka, Ibrahim da sauran bincike sun nuna cewa PRP kadai ba ta da tasiri a cikin maganin vitiligo.Kadry et al.gudanar da binciken da aka bazu kan maganin vitiligo tare da PRP hade tare da carbon dioxide dot matrix laser, kuma ya gano cewa PRP hade da carbon dioxide dot matrix laser da PRP kadai sun sami sakamako mai kyau na haifuwa.Daga cikin su, PRP haɗe da carbon dioxide dot matrix laser yana da mafi kyawun tasirin haifuwa mai launi, kuma PRP kaɗai ya sami haɓakar matsakaicin launi a cikin leukoplakia.Sakamakon haifuwar launi na PRP kadai ya fi na carbon dioxide dot matrix laser kadai a cikin maganin vitiligo.
Aiki Haɗe tare da PRP a cikin Jiyya na Vitiligo
Vitiligo wani nau'in cuta ne na cututtukan launi wanda ke da alaƙa da depigmentation.Hanyoyin jiyya na al'ada sun haɗa da maganin ƙwayoyi, phototherapy ko tiyata, ko haɗin hanyoyin magani da yawa.Ga marasa lafiya tare da barga vitiligo da mummunan sakamako na maganin al'ada, magani na tiyata zai iya zama farkon sa baki.
Garg et al.yi amfani da PRP a matsayin wakili na dakatarwa na kwayoyin epidermal, kuma ya yi amfani da Er: YAG Laser don niƙa fararen fata, wanda ya sami sakamako mai kyau na warkewa a cikin maganin marasa lafiya na vitiligo.A cikin wannan binciken, an shigar da marasa lafiya 10 tare da barga vitiligo kuma an samu raunuka 20.A cikin raunuka na 20, raunuka na 12 (60%) sun nuna cikakkiyar farfadowa na launi, 2 raunuka (10%) sun nuna babban farfadowa na pigment, 4 raunuka (20%) sun nuna matsakaicin farfadowa na launi, kuma 2 raunuka (10%) bai nuna wani ci gaba mai mahimmanci ba.Farfadowa na kafafu, haɗin gwiwa, fuska da wuyansa ya fi bayyana, yayin da farfadowa na gaba ba shi da kyau.
Nimitha et al.sun yi amfani da dakatarwar PRP na sel na epidermal don shirya dakatarwa da phosphate buffer dakatarwa na sel epidermal don kwatanta da lura da farfadowar su a cikin marasa lafiya tare da barga vitiligo.21 barga vitiligo marasa lafiya da aka hada da 42 fararen spots aka samu.Matsakaicin kwanciyar hankali na vitiligo shine shekaru 4.5.Yawancin marasa lafiya sun nuna ƙaramin zagaye zuwa farfaɗowar launi mai hankali game da watanni 1-3 bayan jiyya.A cikin watanni 6 na biyo baya, ma'anar farfadowa na pigment shine 75.6% a cikin ƙungiyar PRP da 65% a cikin ƙungiyar PRP ba.Bambanci na yankin dawo da launi tsakanin ƙungiyar PRP da ƙungiyoyin PRP yana da mahimmanci a ƙididdiga.Ƙungiyar PRP ta nuna mafi kyawun dawo da launi.Lokacin nazarin ƙimar dawo da launi a cikin marasa lafiya tare da vitiligo kashi, babu wani babban bambanci tsakanin ƙungiyar PRP da ƙungiyar PRP.
Aikace-aikacen PRP a Chloasma
Melasma wata nau'in cutar fata ce da aka samu ta fuska, wacce galibi tana faruwa ne akan fuskar matan da suke yawan fuskantar hasken ultraviolet kuma suna da zurfin launin fata.Ba a yi cikakken bayani game da cututtukan da ke haifar da cutar ba, kuma yana da wuyar magani kuma yana da sauƙin dawowa.A halin yanzu, maganin chloasma galibi yana ɗaukar hanyar haɗin gwiwa.Kodayake allurar subcutaneous na PRP yana da hanyoyi daban-daban na magani don chlorasma, ingancin marasa lafiya ba shi da gamsarwa sosai, kuma yana da sauƙin sake dawowa bayan dakatar da jiyya.Kuma magungunan baka irin su tranexamic acid da glutathione na iya haifar da kumburin ciki, rashin jinin al’ada, ciwon kai, har ma da samuwar thrombosis mai zurfi.
Don gano sabon magani ga chlorasma muhimmin alkibla ne a cikin binciken chlorasma.An ba da rahoton cewa PRP na iya inganta haɓakar cututtukan fata na marasa lafiya tare da melasma.Kayi rl da et al.An ruwaito cewa wata mace mai shekaru 27 ta sami allurar microneedle na subcutaneous na PRP kowane kwanaki 15.A ƙarshen jiyya na PRP na uku, an lura cewa yanki na farfadowa na launi na epidermal shine> 80%, kuma babu sake dawowa a cikin watanni 6.Sirithanabadeekul et al.An yi amfani da PRP don maganin chlorasma don yin ƙarin RCT mai tsanani, wanda ya kara tabbatar da ingancin allurar PRP na ciki don maganin chloasma.
Hofny et al.An yi amfani da hanyar immunohistochemical don gudanar da TGF ta hanyar allurar microneedle na subcutaneous na PRP a cikin raunukan fata na marasa lafiya tare da chloasma da sassan al'ada- β Kwatanta maganganun furotin ya nuna cewa kafin maganin PRP, raunin fata na marasa lafiya tare da chloasma da TGF a kusa da raunuka na fata. β Maganar furotin ya kasance ƙasa da ƙasa fiye da na fata mai lafiya (P <0.05).Bayan jiyya na PRP, TGF na raunin fata a cikin marasa lafiya tare da chlorasma-β An ƙara yawan maganganun furotin.Wannan al'amari yana nuna cewa za a iya samun ingantaccen sakamako na PRP akan marasa lafiya na chloasma ta hanyar ƙara TGF na raunuka na fata- β Maganar furotin yana samun sakamako na warkewa akan chlorasma.
Fasahar Wutar Lantarki Haɗe da Allurar Subcutaneous na PRP don Maganin Chloasma
Tare da ci gaba da ci gaba da fasahar photoelectric, rawar da take takawa wajen kula da chlorasma ya jawo hankalin masu bincike da yawa.A halin yanzu, lasers da ake amfani da su don magance chloasma sun haɗa da Laser Q-switched, Laser lattice, haske mai ƙarfi mai ƙarfi, Laser bromide na cuprous da sauran matakan jiyya.Ka'idar ita ce, ana gudanar da zaɓen haske mai zaɓe don ƙwayoyin melanin a ciki ko tsakanin melanocytes ta hanyar zaɓin makamashi, kuma aikin melanocytes yana aiki ko hana shi ta hanyar ƙarancin ƙarfi da fashewar haske mai yawa, kuma a lokaci guda, fashewar haske mai yawa na ƙwayoyin melanin. Ana aiwatar da shi, Yana iya sa barbashi na melanin su ƙanƙanta kuma su fi dacewa da hadiye su da fitar da jiki.
Su Bifeng et al.Chloasma da aka yi da allurar hasken ruwa na PRP haɗe tare da Q switched Nd: YAG 1064nm laser.Daga cikin marasa lafiya 100 tare da chloasma, marasa lafiya 15 a cikin rukunin PRP + Laser sun warke sosai, marasa lafiya 22 sun inganta sosai, marasa lafiya 11 sun inganta, kuma 1 mara lafiya bai da tasiri;A cikin rukunin Laser kadai, shari'o'i 8 sun warke sosai, lokuta 21 sun yi tasiri sosai, an inganta shari'o'i 18, kuma lokuta 3 ba su da tasiri.Bambanci tsakanin ƙungiyoyin biyu yana da mahimmanci a ƙididdiga (P<0.05).Peng Guokai da Song Jiquan sun kara tabbatar da ingancin laser Q-switched hade da PRP wajen maganin chlorasma na fuska.Sakamakon ya nuna cewa laser Q-switched tare da PRP yana da tasiri a maganin chlorasma na fuska
Bisa ga binciken da aka yi a halin yanzu akan PRP a cikin dermatosis mai launi, yiwuwar tsarin PRP a cikin maganin chloasma shine PRP yana ƙara TGF na raunuka fata- β Maganar furotin na iya inganta marasa lafiya na melasma.Haɓakawa na PRP akan cututtukan fata na marasa lafiya na vitiligo na iya zama alaƙa da ƙwayoyin α Adhesion da aka ɓoye ta hanyar granules suna da alaƙa da haɓakar microenvironment na gida na cututtukan vitiligo ta hanyar cytokines.Farawar vitiligo yana da alaƙa da alaƙa da ƙarancin rigakafi na raunukan fata.Nazarin ya gano cewa ƙananan ƙwayoyin cuta na gida na marasa lafiya na vitiligo suna da alaƙa da gazawar keratinocytes da melanocytes a cikin raunuka na fata don tsayayya da lalacewar melanocytes da ke haifar da nau'o'in ƙwayoyin cuta da kuma chemokines da aka saki a cikin tsarin damuwa na intracellular oxidative.Koyaya, nau'ikan abubuwan haɓakar platelet da aka ɓoye ta PRP da nau'ikan cytokines na anti-inflammatory waɗanda aka saki ta platelet, kamar su mai narkewa necrosis factor receptor I, IL-4 da IL-10, waɗanda suke antagonists na mai karɓar interleukin-1, na iya. taka wata rawa wajen daidaita ma'auni na rigakafi na gida na raunukan fata.
(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)
Lokacin aikawa: Nuwamba-24-2022