PRP yana aiki ta hanyar lalata alpha granules daga platelet, wanda ya ƙunshi abubuwan haɓaka da yawa.Sirri mai aiki na waɗannan abubuwan haɓaka yana farawa ta hanyar tsarin coagulation na jini kuma yana farawa a cikin mintuna 10 na coagulation.Fiye da 95% na abubuwan haɓaka da aka riga aka haɗa ana ɓoye su cikin sa'a 1.Don haka, dole ne a shirya PRP a cikin yanayin maganin jijiyar jini kuma yakamata a yi amfani da shi a cikin grafts, flaps, ko raunuka a cikin mintuna 10 na farawar jini.Nazarin da ba sa amfani da maganin rigakafi gaba ɗaya ba karatun PRP na gaskiya bane kuma suna yaudara.
Kamar yadda platelets ke kunna ta hanyar tsarin clotting, abubuwan haɓaka suna ɓoyewa daga tantanin halitta ta cikin membrane cell.A cikin wannan tsari, ƙwayoyin alpha suna haɗuwa zuwa membranes cell membranes, kuma abubuwan haɓaka sunadaran suna kammala yanayin bioactive ta hanyar ƙara sassan tarihin tarihi da carbohydrate zuwa waɗannan sunadaran.Don haka, platelets sun lalace ko rashin kunna su ta hanyar jiyya ta PRP ba sa ɓoye abubuwan haɓakar ƙwayoyin cuta kuma suna iya haifar da sakamako mara daɗi.Abubuwan haɓaka da aka ɓoye suna ɗaure kai tsaye zuwa saman farfajiyar membrane na sel a cikin ƙwanƙwasa, kada, ko rauni ta hanyar masu karɓan transmembrane.
Nazarin ya nuna cewa tsofaffin ƙwayoyin jikin mutum na mesenchymal, osteoblasts, fibroblasts, sel endothelial, da kwayoyin epidermal suna bayyana masu karɓa na cell membrane don abubuwan haɓaka a cikin PRP.Wadannan masu karɓa na transmembrane bi da bi suna haifar da kunna ƙwayoyin sigina na ciki na ciki wanda ke haifar da furci (buɗewa) na jerin kwayoyin halitta na yau da kullum, irin su yaduwar kwayar halitta, haɓakar matrix, samuwar osteoid, haɓakar collagen, da dai sauransu.
Muhimmancin wannan ilimin shine cewa abubuwan haɓakar PRP ba su taɓa shiga cikin tantanin halitta ko tsakiya ba, ba su da mutagenic, kawai suna hanzarta haɓakar warkarwa ta al'ada.Saboda haka, PRP ba shi da ikon haifar da ƙwayar cuta.
Bayan fashewar farko na abubuwan haɓaka masu alaƙa da PRP, platelets suna haɗawa da ɓoye ƙarin abubuwan haɓaka don sauran kwanaki 7 na tsawon rayuwarsu.Da zarar platelets sun ƙare kuma sun mutu, macrophages da ke isa yankin ta hanyar jini mai motsa jini suna girma a ciki don ɗaukar nauyin mai kula da raunin rauni ta hanyar ɓoye wasu abubuwan haɓaka iri ɗaya da sauransu.Don haka, adadin platelets a cikin daska, rauni, ko ɗigon jini da ke manne da murɗa yana ƙayyade yadda raunin ya warke da sauri.PRP kawai ta ƙara zuwa wannan lambar.
Nawa platelets sun isa?
Nazarin ya nuna cewa yaduwa da bambance-bambancen MSCS na manya suna da alaƙa kai tsaye da tattarawar platelet.Sun nuna matakan amsa kashi, wanda ke nuni da cewa isassun martanin salon salula ga maida hankali na platelet ya fara farawa lokacin da aka kai sau hudu zuwa biyar.Wani bincike mai kama da haka ya nuna cewa ƙara yawan ƙwayar platelet ya kuma inganta haɓakar fibroblast da kuma nau'in samar da collagen na I, kuma yawancin amsa ya dogara da PH, tare da mafi kyawun amsawa yana faruwa a mafi yawan matakan pH acid.
Waɗannan karatun ba wai kawai suna nuna buƙatar na'urori don tattara isassun platelets ba, amma kuma sun bayyana ingantaccen sakamakon haɓakar ƙashi da haɓakar ƙwayoyin laushi masu alaƙa da PRP.
Tun da yawancin mutane suna da ƙididdige adadin platelet na 200,000 ± 75,000 a kowace μl, ƙididdigar PRP na 1 miliyan a kowace μl da aka auna a cikin daidaitattun 6-ml aliquots ya zama ma'auni na "PRP na warkewa."Mahimmanci, bincike ya nuna cewa ana samun wannan taro na platelet lokacin da aka kai matakan jiyya, ta haka ne ke sakin abubuwan girma.
(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)
Lokacin aikawa: Satumba-01-2022