Androgenic alopecia (AGA) wani nau'in asarar gashi ne na yau da kullun da ke haifar da gado da kuma hormones, wanda ke siffanta shi da ɓarkewar gashin kai.Daga cikin masu shekaru 60, 45% na maza da 35% na mata suna fuskantar matsalar AGA.FDA ta amince da ka'idojin jiyya na AGA sun haɗa da finasteride na baka da minoxidil na Topical.A halin yanzu, saboda rashin ingantaccen magani, PRP ya zama sabon magani mai ban sha'awa.Babban adadin abubuwan haɓakawa a cikin PRP na iya haɓaka haɓakar gashi da platelet α Abubuwan haɓaka iri-iri da aka ɓoye ta granules suna aiki akan sel mai tushe a cikin yanki mai kumbura gashi kuma suna haɓaka samuwar sabbin hanyoyin jini.Kodayake labarai da yawa sun ba da rahoton wannan, babu ƙayyadaddun ƙa'ida don shirye-shiryen PRP, hanyar gudanarwa da kimanta sakamakon asibiti.Wannan labarin yana nufin kimanta tasiri na PRP a cikin maganin AGA da kuma gano nau'o'in jiyya daban-daban.
Tsarin aiki na PRP:
Ana kunna PRP bayan an yi masa allura a cikin fatar kan mutum don sakin adadin abubuwan haɓaka da haɓaka gashi.Wadannan abubuwan haɓaka suna iya kunna fibroblasts, haɓaka haɓakar collagen, haɓaka haɓakar matrix na extracellular da daidaita maganganun abubuwan haɓakar endogenous.Abubuwan haɓaka (PDGF, TGF- β, VEGF, EGF, IGF-1) na iya haɓaka haɓakar ƙwayoyin cuta da rarrabuwa, ƙwayoyin ƙwayoyin cuta na chemotactic, haifar da haɓakar gashi mai tsayi, da haɓaka haɓakar angiogenesis na gashi.Sauran abubuwan (serotonin, histamine, dopamine, calcium da adenosine) na iya ƙara haɓakar membrane da daidaita kumburi.
Shirye-shiryen PRP:
Duk shirye-shiryen shirye-shiryen PRP suna bin ka'ida ta gaba ɗaya, kuma ana ƙara magungunan kashe jini (kamar citrate) a cikin jinin da aka tattara don guje wa coagulation na kwatsam da kunna platelet.Centrifuge don cire jajayen ƙwayoyin jini da tattara platelets.Bugu da kari, da yawa tsare-tsare zabi exogenous platelet activators (kamar thrombin da calcium chloride) don inganta saurin sakin abubuwan girma daga platelet a cikin hanyar dogaro da kashi.Hakanan ana iya kunna platelets marasa aiki ta dermal collagen ko autothrombin.Gabaɗaya, abubuwan haɓaka mai aiki suna ɓoye bayan mintuna 10 bayan kunnawa, kuma ana fitar da kashi 95% na abubuwan haɓakar haɓakar haɓaka a cikin sa'a 1, yana ɗaukar mako 1.
Tsarin jiyya da maida hankali:
Yawancin lokaci ana yi wa PRP allurar subcutaneously ko a cikin fata.A halin yanzu, ba a kafa mafi kyawun mitar magani da tazara ba.Ƙaddamar da PRP shine muhimmin mahimmanci wanda ke shafar tasirin asibiti.Labari bakwai da aka haɗa sun gabatar da cewa mafi kyawun ƙaddamarwa na PRP shine sau 2 ~ 6, kuma ƙaddamarwa mai yawa zai hana angiogenesis.Har yanzu akwai sabani game da ko yana dauke da fararen jini.
Sakamakon bincike na yanzu ya nuna cewaAna iya amfani da PRP a cikin maganin AGA.Bakwai daga cikin binciken tara sun bayyana sakamako mai kyau.An kimanta ingancin PRP daga ra'ayoyi da yawa: Hanyar gano PTG, gwajin tashin hankali gashi, ƙidayar gashi da yawan gashi, lokacin girma zuwa rabon lokacin hutu, da binciken gamsuwar haƙuri.Wasu nazarin kawai sun ba da rahoton ingantaccen sakamako na biyan kuɗi na watanni 3 bayan jiyya na PRP, amma ba su da sakamako na watanni 6.Wasu binciken bincike na tsawon lokaci (6 zuwa 12 watanni) sun ba da rahoton raguwar yawan gashi, amma har yanzu ya fi matakin tushe.An ba da rahoton sakamako masu illa a matsayin jin zafi na wucin gadi a yankin allura.Ba a ba da rahoton wani mummunan martani ba.
Nasihar magani:
Tun da PRP ba ta hana matakin hormone da ke da alaka da AGA ba, ana bada shawarar cewa a yi amfani da PRP a matsayin maganin adjuvant don AGA.Sabili da haka, ya kamata a ƙarfafa marasa lafiya su kula da magunguna na waje ko na baki (irin su minoxidil, spironolactone da finasteride).Dangane da wannan binciken na baya-bayan nan, ana bada shawarar shirya P-PRP (leukopenia) tare da maida hankali sau 3-6 na jini duka.Yin amfani da masu kunnawa (calcium chloride ko calcium gluconate) kafin magani yana taimakawa wajen sakin abubuwan haɓaka.An ba da shawarar cewa a yi allurar da ke ƙarƙashin fata daga sashin da ba shi da ƙarancin gashi, tare da layin gashi da sama, kuma a ware wuraren allurar.An ƙayyade adadin allura ta hanyar buƙatun asibiti.Ana zabar mitar allurar a farkon tsarin jiyya (sau ɗaya a wata, sau uku a jimlace, watanni uku), sannan kuma sau ɗaya kowane wata uku, sau uku gabaɗaya (wato sau ɗaya a watan Yuni, Satumba da Disamba bi da bi).Tabbas, bayan tsarin farko na jiyya, yana da tasiri don canza lokacin tazara zuwa sau ɗaya kowane watanni shida.Gabaɗaya, marasa lafiya maza da mata sun sami sakamako mai kyau a cikin haɓakar gashi, haɓaka haɓakar gashi da ingancin rayuwa bayan allurar PRP don magance AGA (Hoto 1 da Hoto 2).
Ƙarshe:
Binciken sakamakon bincike da yawa ya nuna cewa PRP yana da alƙawarin yin maganin AGA.A lokaci guda, magani na PRP yana da alama ya fi aminci da ƙarancin sakamako masu illa.Duk da haka, har yanzu akwai rashin daidaitattun hanyar shirye-shiryen PRP, maida hankali, tsarin allura, sashi, da dai sauransu. Saboda haka, yana da wuya a kimanta tasirin asibiti na PRP.Don ci gaba da nazarin tasirin PRP akan farfadowar gashi a cikin AGA, ana buƙatar babban girman samfurin gwaji na gwaji (lura da yawan allura, maida hankali na PRP, da samun biyan kuɗi na dogon lokaci).
(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)
Lokacin aikawa: Dec-08-2022