Tarihin Platelet Rich Plasma (PRP)

Game da Platelet Rich Plasma (PRP)

Platelet-rich Plasma (PRP) yana da kwatankwacin ƙimar warkewa ga sel kuma a halin yanzu yana ɗaya daga cikin abubuwan da aka fi dacewa da maganin warkewa a cikin maganin farfadowa.Ana ƙara yin amfani da shi a fannonin likitanci daban-daban, waɗanda suka haɗa da kayan kwalliyar fata, likitan kasusuwa, likitancin wasanni da tiyata.

A cikin 1842, an gano wasu sifofi ban da ja da fari a cikin jini, wanda ya ba mutanen zamaninsa mamaki.Julius Bizozero shine farkon wanda ya fara suna sabon tsarin platelet "le piastrine del sangue" - platelets.A cikin 1882, ya bayyana rawar platelet a cikin coagulation a cikin vitro da kuma shigar da su a cikin etiology na thrombosis a cikin vivo.Ya kuma gano cewa bangon jijiyoyin jini yana hana mannewar platelet.Wright ya ci gaba da ci gaba da haɓaka dabarun farfadowa tare da bincikensa na macrokaryocytes, waɗanda ke gabatowar platelet.A farkon 1940s, likitocin sun yi amfani da "tsarin ciki" na ciki wanda ya ƙunshi abubuwan girma da cytokines don inganta warkar da rauni.Saurin warkar da raunuka yana da mahimmanci ga nasarar hanyoyin tiyata.Saboda haka, Eugen Cronkite et al.ya gabatar da haɗin thrombin da fibrin a cikin fata.Ta yin amfani da abubuwan da ke sama, an tabbatar da tabbataccen abin da aka makala maɗaure mai ƙarfi, wanda ke taka muhimmiyar rawa a irin wannan aikin tiyata.

A farkon karni na 20, likitocin sun fahimci buƙatar gaggawa don gabatar da jini na platelet don magance thrombocytopenia.Wannan ya haifar da haɓakawa a cikin dabarun shirye-shiryen tattarawar platelet.Ƙarawa tare da tattarawar platelet zai iya hana zubar jini a cikin marasa lafiya.A lokacin, likitocin da likitocin jini na dakin gwaje-gwaje sun yi ƙoƙarin shirya abubuwan da ke tattare da platelet don ƙarin jini.Hanyoyi don samun abubuwan tattarawa sun haɓaka cikin sauri kuma sun inganta sosai, saboda keɓaɓɓen faranti da sauri suna rasa ƙarfin su kuma dole ne a adana su a 4 ° C kuma a yi amfani da su cikin sa'o'i 24.

Kaya da matakai

A cikin 1920s, an yi amfani da citrate azaman maganin ƙwanƙwasa don samun abubuwan da ke tattare da platelet.Ci gaba a cikin shirye-shiryen tattarawar platelet ya haɓaka a cikin 1950s da 1960s lokacin da aka ƙirƙiri kwantena filastik masu sassauƙa.Kalmar "plasma mai arzikin platelet" Kingsley et al ne ya fara amfani da ita.a cikin 1954 don komawa ga daidaitattun abubuwan tattarawar platelet da ake amfani da su don ƙarin jini.Tsarin bankin jini na farko na PRP ya bayyana a cikin 1960s kuma ya zama sananne a cikin 1970s.A ƙarshen 1950s da 1960s, an yi amfani da "fakitin platelet EDTA".Saitin yana ƙunshe da jakar filastik tare da jinin EDTA wanda ke ba da damar platelets su tattara su ta hanyar centrifugation, wanda ya rage a dakatar da shi a cikin ƙaramin adadin plasma bayan tiyata.

Sakamako

Ana hasashen cewa abubuwan haɓaka (GFs) sune ƙarin mahadi na PRP waɗanda ke ɓoye daga platelet kuma suna cikin aikin sa.An tabbatar da wannan hasashe a cikin 1980s.Ya zama cewa platelets suna sakin kwayoyin halittu masu rai (GFs) don gyara nama da suka lalace, kamar ciwon fata.Har ya zuwa yau, an gudanar da ƴan binciken da ke bincika wannan batu.Ɗaya daga cikin batutuwan da aka fi nazari a wannan fanni shine haɗin PRP da hyaluronic acid.Cohen ya gano nau'in girma na Epidermal (EGF) a cikin 1962. GFs na gaba sun kasance nau'in haɓakar haɓakar platelet (PDGF) a cikin 1974 da kuma haɓakar haɓakar haɓakar jijiyoyi (VEGF) a cikin 1989.

Gabaɗaya, ci gaban magani kuma ya haifar da saurin ci gaba a aikace-aikacen platelet.A cikin 1972, Matras ya fara amfani da platelets a matsayin abin rufewa don kafa homeostasis na jini yayin tiyata.Bugu da ƙari kuma, a cikin 1975, Oon da Hobbs sune masana kimiyya na farko da suka yi amfani da PRP a sake ginawa.A cikin 1987, Ferrari et al ya fara amfani da plasma mai arzikin platelet a matsayin tushen samun ƙarin jini a cikin aikin tiyata na zuciya, ta haka yana rage asarar jini na ciki, rikicewar jini na kewayawar huhu, da kuma amfani da samfuran jini na gaba.

A cikin 1986, Knighton et al.sune masana kimiyya na farko da suka bayyana ƙa'idar haɓakar platelet kuma suka sanya mata suna autologous platelet-derived raunin warkar da rauni (PDWHF).Tun lokacin da aka kafa wannan yarjejeniya, ana ƙara amfani da dabarar a cikin magungunan kwalliya.An yi amfani da PRP a cikin maganin farfadowa tun daga ƙarshen 1980s.

Baya ga aikin tiyata na gabaɗaya da tiyatar zuciya, tiyata maxillofacial wani yanki ne inda PRP ta shahara a farkon shekarun 1990.An yi amfani da PRP don inganta haɗin gwiwa a cikin sake gina mandibular.An kuma fara aiwatar da PRP a likitan hakora kuma ana amfani dashi tun daga ƙarshen 1990s don inganta haɗin haɗin haƙori da inganta haɓakar kashi.Bugu da ƙari, manne fibrin sanannen abu ne mai alaƙa da aka gabatar a lokacin.An ci gaba da yin amfani da PRP a likitan haƙori tare da ƙirƙira fibrin mai arzikin platelet (PRF), ƙwayar platelet wanda ba ya buƙatar ƙarin magungunan rigakafin jini, ta Choukroun.

PRF ya zama sananne a farkon 2000s, tare da karuwar yawan aikace-aikace a cikin hanyoyin hakori, ciki har da sake farfadowa da nama na gingival hyperplastic da lahani na lokaci-lokaci, ƙulla raunuka na palatal, maganin koma bayan gingival, da kuma cire hannayen riga.

Tattaunawa

Anitua a cikin 1999 ya bayyana amfani da PRP don inganta haɓakar kashi yayin musayar jini.Bayan lura da fa'idar maganin, masana kimiyyar sun kara bincikar lamarin.Takardunsa na gaba sun ba da rahoton tasirin wannan jini akan cututtukan fata na yau da kullun, dasa hakori, warkar da tendon, da raunin wasanni na orthopedic.An yi amfani da magunguna da yawa waɗanda ke kunna PRP, irin su calcium chloride da thrombin bovine, tun daga 2000.

Saboda kyawawan kaddarorin sa, ana amfani da PRP a cikin orthopeedics.Sakamakon bincike mai zurfi na farko game da tasirin abubuwan haɓakawa akan ƙwayar tsoka na ɗan adam an buga shi a cikin 2005. A halin yanzu ana amfani da maganin PRP don magance cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan ƙwayoyin cuta da ƙwayoyin cuta da ƙwayoyin cuta.Bincike ya nuna cewa ci gaba da shaharar hanyar da ake yi a cikin orthopedics na iya kasancewa da alaƙa da yawan amfani da PRP ta taurarin wasanni.A cikin 2009, an buga wani binciken dabba na gwaji wanda ya tabbatar da ra'ayin cewa PRP yana mayar da hankali kan inganta ƙwayar tsoka.Hanyar da ta dace na aikin PRP a cikin fata a halin yanzu shine batun binciken kimiyya mai zurfi.

An yi amfani da PRP cikin nasara a cikin gyaran fata tun daga 2010 ko baya.Bayan allurar PRP, fata ya zama ƙarami da hydration, sassauci da launi suna inganta sosai.Ana kuma amfani da PRP don inganta haɓakar gashi.Akwai nau'ikan PRP guda biyu a halin yanzu ana amfani da su don maganin haɓakar gashi - plasma mai wadatar platelet mara aiki (A-PRP) da plasma mai wadatar platelet (AA-PRP).Duk da haka, Gentile et al.ya nuna cewa za a iya inganta yawan gashi da ma'aunin ƙididdiga na gashi ta hanyar allurar A-PRP.Bugu da ƙari, an tabbatar da cewa yin amfani da maganin PRP kafin a dasa gashi na iya haɓaka haɓakar gashi da yawan gashi.Bugu da ƙari, a cikin 2009, nazarin ya nuna cewa yin amfani da cakuda PRP da mai zai iya inganta karɓuwa da kuma rayuwa, wanda zai iya inganta sakamakon tiyata na filastik.

Sabbin binciken da aka samu daga Cosmetic Dermatology ya nuna cewa haɗin PRP da CO2 maganin Laser na iya rage yawan kurajen fuska.Hakazalika, PRP da microneedling sun haifar da mafi yawan tsararrun ƙwayoyin collagen a cikin fata fiye da PRP kadai.Tarihin PRP ba takaice ba ne, kuma binciken da ya danganci wannan bangaren jini yana da mahimmanci.Likitoci da masana kimiyya suna neman sabbin hanyoyin magani.A matsayin ma'ana, ana amfani da PRP a fannonin likitanci da yawa, gami da ilimin mata, urology, da kuma ophthalmology.

Tarihin PRP ya kai shekaru 70 a kalla.Saboda haka, hanyar da aka kafa da kyau kuma ana iya amfani dashi a cikin magani.

(Ana sake buga abubuwan da ke cikin wannan labarin, kuma ba mu bayar da garantin bayyananne ko bayyananniyar garanti don daidaito, amintacce ko cikar abubuwan da ke cikin wannan labarin ba, kuma ba mu da alhakin ra'ayoyin wannan labarin, da fatan za a fahimta.)