Allura biyu ko hudu na plasma mai arzikin platelet a cikin gwiwa na osteoarthritis bai canza masu biomarkers na synovial ba, amma kuma sun inganta sakamakon asibiti.
Bisa ga gwajin ƙwararrun masana'antu masu dacewa, sun kwatanta biyu da hudu intra-articular injections na platelet-rich plasma (PRP) game da canje-canje a cikin cytokines synovial da sakamakon asibiti.Marasa lafiya 125 masu fama da osteoarthritis na gwiwa (OA) sun sami allurar PRP kowane mako 6.Kafin kowace allurar PRP, an tattara buƙatun ruwa na synovial don nazari.An raba marasa lafiya zuwa biyu ko hudu intra-articular PRP injections (rukunin A da B, bi da bi).Canje-canje a cikin biomarkers na synovial an kwatanta su da matakan asali a cikin ƙungiyoyi biyu, kuma an kiyasta sakamakon asibiti har zuwa shekara guda.
Marasa lafiya casa'in da huɗu waɗanda suka kammala tattara ruwan synovial sun haɗa su a cikin kimantawa na ƙarshe, 51 a cikin rukunin A da 43 a cikin rukunin B. Babu bambance-bambance a cikin matsakaicin shekaru, jima'i, ƙididdigar jiki (BMI), da darajar OA na rediyo.Ma'anar ma'anar platelet da adadin jinin jini a cikin PRP sune 430,000 / µL da 200 / µL, bi da bi. -4, IL-10, IL-13, da IL-1RA) ba su canza ba, kuma Abubuwan haɓaka (TGF-B1, VEGF, PDGF-AA da PDGF-BB) sun kasance a cikin tushe kuma tsakanin makonni 6 a rukunin A da 18 makonni. a rukunin B.
Sakamakon asibiti a cikin ƙungiyoyin biyu sun inganta sosai daga makonni na 6, ciki har da Siffar Analog Analog (VAS), Ma'auni na Sakamakon Sakamakon Mai haƙuri [PROMs;Western Ontario da McMaster Jami'o'in Osteoarthritis (WOMAC) Index da Short Form-12 (SF-12)], matakan tushen aiki [PBMs;lokacin tashi (TUG), 5 sit-stand tests (5 × SST), da gwajin tafiya na mintuna 3 (minti 3 WT)] A ƙarshe, 2 ko 4 intra-articular injections na PRP kowane mako 6 a gwiwa. OA bai nuna canje-canje a cikin cytokines na synovial da abubuwan haɓaka ba, amma kuma ya inganta sakamakon asibiti daga makonni 6 zuwa shekara 1.
Lokacin aikawa: Maris-03-2022